![]() ![]() The prospectively planned STOPCAP meta-analysis, published alongside STAMPEDE, showed substantial, reliable evidence that upfront docetaxel improved survival for men with metastatic disease ( 7). Trials of docetaxel in this setting reported before STAMPEDE showed inconsistent results in locally advanced disease: Upfront docetaxel improved relapse-free survival (survival not reported) in nonmetastatic disease in GETUG-12 ( 2) improved failure-free survival (FFS) and progression-free survival (PFS) in metastatic disease without evidence of improvement in overall survival in GETUG-15’s primary and long-term analyses ( 3, 4) and a survival benefit in metastatic disease in CHAARTED’s early released and long-term analyses ( 5, 6). ![]() ![]() STAMPEDE’s “docetaxel comparison” previously showed a clear, clinically important overall survival advantage for adding upfront docetaxel across men with locally advanced or metastatic prostate cancer initiating long-term androgen deprivation therapy (ADT) ( 1). Nicholas D James, PhD, Fiona C Ingleby, PhD, Noel W Clarke, FRCS(Urol), Claire L Amos, PhD, Gerhardt Attard, PhD, Christopher D Brawley, MSc, Simon Chowdhury, PhD, William Cross, FRCS(Urol), David P Dearnaley, FRCP, Duncan C Gilbert, PhD, Silke Gillessen, PD venia docendi, Robert J Jones, PhD, Ruth E Langley, PhD, Archie Macnair, FRCR, Zafar I Malik, FRCR, Malcolm D Mason, PhD, David J Matheson, PhD, Robin Millman, Chris C Parker, MD, Hannah L Rush, MBChB, J Martin Russell, MBChB, Carly Au, BSc, Alastair W S Ritchie, MD, FRCSEd, Ricardo Pereira Mestre, MD, Imtiaz Ahmed, MCRP, FRCR, Alison J Birtle, MBBS, MRCP, FRCR, Susannah J Brock, FRCR, MRCP, BM BCh, Prantik Das, MBBS, MRCP, FRCR, Victoria A Ford, PhD, Emma K Gray, FRCR, Robert J Hughes, MRCP, FRCR, Caroline B Manetta, FRCR, Duncan B McLaren, FRCR FRCP, Ashok D Nikapota, MRCP, FRCR, Joe M O’Sullivan, FRCR, Carla Perna, MBBC, FRCR (equiv), Clive Peedell, MRCP, FRCR, Andrew S Protheroe, FRCP, PhD, Santhanam Sundar, MRCP, FRCR, Jacob S Tanguay, MBChB, FRCR, Shaun P Tolan, MBChB, FRCR, John Wagstaff, MBChB, MD, CCT, Jan B Wallace, FRCR, James P Wylie, MRCP, FRCR, Anjali Zarkar, FRCS, Mahesh K B Parmar, DPhil, and Matthew R Sydes, MSc CStat ![]()
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