![]() ![]() The prospectively planned STOPCAP meta-analysis, published alongside STAMPEDE, showed substantial, reliable evidence that upfront docetaxel improved survival for men with metastatic disease ( 7). Trials of docetaxel in this setting reported before STAMPEDE showed inconsistent results in locally advanced disease: Upfront docetaxel improved relapse-free survival (survival not reported) in nonmetastatic disease in GETUG-12 ( 2) improved failure-free survival (FFS) and progression-free survival (PFS) in metastatic disease without evidence of improvement in overall survival in GETUG-15’s primary and long-term analyses ( 3, 4) and a survival benefit in metastatic disease in CHAARTED’s early released and long-term analyses ( 5, 6). ![]() ![]() STAMPEDE’s “docetaxel comparison” previously showed a clear, clinically important overall survival advantage for adding upfront docetaxel across men with locally advanced or metastatic prostate cancer initiating long-term androgen deprivation therapy (ADT) ( 1). Nicholas D James, PhD, Fiona C Ingleby, PhD, Noel W Clarke, FRCS(Urol), Claire L Amos, PhD, Gerhardt Attard, PhD, Christopher D Brawley, MSc, Simon Chowdhury, PhD, William Cross, FRCS(Urol), David P Dearnaley, FRCP, Duncan C Gilbert, PhD, Silke Gillessen, PD venia docendi, Robert J Jones, PhD, Ruth E Langley, PhD, Archie Macnair, FRCR, Zafar I Malik, FRCR, Malcolm D Mason, PhD, David J Matheson, PhD, Robin Millman, Chris C Parker, MD, Hannah L Rush, MBChB, J Martin Russell, MBChB, Carly Au, BSc, Alastair W S Ritchie, MD, FRCSEd, Ricardo Pereira Mestre, MD, Imtiaz Ahmed, MCRP, FRCR, Alison J Birtle, MBBS, MRCP, FRCR, Susannah J Brock, FRCR, MRCP, BM BCh, Prantik Das, MBBS, MRCP, FRCR, Victoria A Ford, PhD, Emma K Gray, FRCR, Robert J Hughes, MRCP, FRCR, Caroline B Manetta, FRCR, Duncan B McLaren, FRCR FRCP, Ashok D Nikapota, MRCP, FRCR, Joe M O’Sullivan, FRCR, Carla Perna, MBBC, FRCR (equiv), Clive Peedell, MRCP, FRCR, Andrew S Protheroe, FRCP, PhD, Santhanam Sundar, MRCP, FRCR, Jacob S Tanguay, MBChB, FRCR, Shaun P Tolan, MBChB, FRCR, John Wagstaff, MBChB, MD, CCT, Jan B Wallace, FRCR, James P Wylie, MRCP, FRCR, Anjali Zarkar, FRCS, Mahesh K B Parmar, DPhil, and Matthew R Sydes, MSc CStat ![]()
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1/30/2024 0 Comments System shock 2 hybrids![]() ![]() Thanks to SS2, I'm convinced to this day that all monkeys hide psionic powers and plan to overthrow us.īecause SS2 provides so few resources, I found myself hoarding ammo, health and psionic hypos though most of the game, and relying on melee attacks with the wrench. The logs also show off the game's impressive audio design, particularly in the menacing sounds of hybrids and cybernetic midwives. The vocal performances in these logs are as chilling now as they were in 1999 – listening to the horror descend on the crew intensifies the terror of your own predicament. System Shock 2's backstory is told through audio logs discovered throughout the ship, a storytelling trope that has inspired lots of modern games. But while the studio's later games are shinier, its first outing is both more complex and, ultimately, more terrifying. Nothing builds fear and tension like isolation, with limited resources and no one to help you. ![]() Irrational Games' first game is where it developed the mechanics familiar to anyone who's played BioShock: build a world the player wants to explore, drop them in, and watch them uncover how that world fell apart. System Shock 2 is about fear and scarcity above all else. But it sees me, shoves its shotgun out and shouts, “Kill. Seizing my chance, I rush out, holding the mouse button down in order to prep my wrench swing. ![]() My only chance is to bludgeon it with a wrench before its friends show up. I have no ammo, and I'm out of psi-hypos. there?” I hear it ask, dragging a shotgun along and searching for the intruder – me. I lean around the corner quickly to look, catching the back of its head as it turns the corner. I can hear it through the door, wandering around the hallway. ![]() 1/30/2024 0 Comments Pizza tower peppino face![]() ![]() ![]() Sewer Pipes are two different colored pipes. He is a chef that seeks to protect his pizza place from the … Peshino is a miscellaneous character in Pizza Tower. He has a dirty goblin face with a long nose, a toothy grin, pointed ears, and black beady eyes. The 4 star, 236-room hotel … Benny’s, a pizza place known for its “Virginia slice” and jumbo 28-inch pies, has made its way to Virginia Beach’s Town Center. Like Fake Peppino, In the lab background of WAR, Pillar … Peppino Spaghetti, commonly referred to as simply Peppino, is the protagonist of the platforming game Pizza Tower. Pizza Tower Guy is omnipresent level editor build Pizza Tower Online Peppino and Anton are canonically friends Peppino and Anton are canonically lovers (joke entry) bacon room Mr. ![]() Ghostknight floats around and hurts the player if touched from the front. Kentucky Kenny walks around and throws spicy chicken wings at Peppino, who will gulp it down from the air, activating the Firemouth transformation. Within it, a library and storage room are found. Like them, Laxa is retired from the … She is the only child of the couple. Electric Potato … Chef Tasks are in-game achievements unlocked in Pizza Tower. This build mostly finishes every level and gives a big overhaul to the game. Benny Cavalloni’s opened on Market … Laxa greets a klatch of men in their 70s and 80s. He is the old business rival of Peppino Spaghetti who went on to create and oversee the Pizza Tower with the intent of using it to destroying Peppino's pizzeria. Gameplay concepts for Peppino Pizza, staring the adventurous chef and rat. Fandom Muthead Futhead Fanatical Follow Us. Clownmato is a bright red balloon tomato wearing clown makeup and a clown nose. In every level of the Pizza Tower, he must collect his babes. 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